GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Serpine1 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of SERPINE1 mRNA; Lipopolysaccharides results in increased expression of SERPINE1 protein | PMID:11779202 PMID:16415329 PMID:17698507 PMID:27224288 | Serpine1 | multiple interactions | EXP | | 6480464 | CTD | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]; [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein] | PMID:16401727 PMID:16415329 PMID:17698507 PMID:27224288 | Serpine1 | affects expression | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides affects the expression of SERPINE1 mRNA | PMID:28070326 | Serpine1 | increases expression | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of SERPINE1 mRNA; Lipopolysaccharides results in increased expression of SERPINE1 protein | PMID:19367693 PMID:22169119 PMID:25890327 PMID:31499194 PMID:9102164 | Serpine1 | increases expression | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of SERPINE1 mRNA; Lipopolysaccharides results in increased expression of SERPINE1 protein | PMID:16317058 PMID:35953652 PMID:9102164 | Serpine1 | increases secretion | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of SERPINE1 protein | PMID:16320596 PMID:17513194 | Serpine1 | multiple interactions | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; [Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA; Cathelicidins inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]; Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 mRNA]; Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]; SERPINE1 protein results in increased susceptibility to [trovafloxacin co-treated with Lipopolysaccharides]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein] | PMID:19367693 PMID:21731756 PMID:22169119 PMID:31499194 PMID:9102164 | Serpine1 | multiple interactions | ISO | SERPINE1 (Homo sapiens) | 6480464 | CTD | [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of SERPINE1 mRNA; [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]]; Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]; Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of SERPINE1 mRNA] | PMID:16317058 PMID:16320596 PMID:22777745 PMID:28070326 PMID:35877022 PMID:9102164 | | ||||||||||||||||||||||
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