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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3188
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch2
Name: notch receptor 2
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch2decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of NOTCH2 mRNAPMID:21266533
Notch2increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of NOTCH2 mRNAPMID:15829613
Notch2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NOTCH2 promoter; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of NOTCH2 mRNAPMID:23359474 PMID:25607892
Notch2decreases expressionISONotch2 (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of NOTCH2 protein alternative formPMID:37277016
Notch2multiple interactionsISONotch2 (Mus musculus)6480464CTD3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form]; Dibutyl Phthalate inhibits the reaction [NOTCH2 protein alternative form binds to BECN1 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form]; NOTCH2 protein alternative form inhibits the reaction [Dibutyl Phthalate results in decreased expression of HES1 mRNA]; NOTCH2 protein alternative form inhibits the reaction [Dibutyl Phthalate results in decreased expression of HEY2 mRNA]PMID:37277016
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