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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3187
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch1
Name: notch receptor 1
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1affects localizationISONotch1 (Mus musculus)6480464CTDZinc affects the localization of NOTCH1 proteinPMID:17513037
Notch1decreases activityISONotch1 (Mus musculus)6480464CTDZinc results in decreased activity of NOTCH1 proteinPMID:17513037
Notch1multiple interactionsISONotch1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]; Wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; Wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]PMID:17513037
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