GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Myc | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of MYC mRNA | PMID:32145629 | Myc | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of MYC mRNA | PMID:2118345 PMID:21980073 | Myc | multiple interactions | EXP | | 6480464 | CTD | Estradiol promotes the reaction [EGF protein results in increased expression of MYC mRNA] | PMID:12632255 | Myc | affects expression | ISO | MYC (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of MYC mRNA | PMID:21826169 | Myc | affects localization | ISO | MYC (Homo sapiens) | 6480464 | CTD | Estradiol affects the localization of MYC protein | PMID:16327978 | Myc | increases expression | ISO | Myc (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of MYC mRNA; Estradiol results in increased expression of MYC protein | PMID:23684557 PMID:8390853 | Myc | increases expression | ISO | MYC (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of MYC mRNA; Estradiol results in increased expression of MYC protein; Estradiol results in increased expression of MYC protein alternative form | PMID:11896290 PMID:15072547 PMID:15319301 PMID:15528270 PMID:15833885 PMID:16051634 PMID:16093440 PMID:16155795 PMID:16327978 PMID:16474171 PMID:16839579 PMID:17266178 PMID:18556351 PMID:18997820 PMID:19244106 PMID:19584281 PMID:19647730 PMID:19654927 PMID:19838210 PMID:20049119 PMID:20106945 PMID:20204298 PMID:20945400 PMID:22453024 PMID:23019147 PMID:23094148 PMID:24758408 PMID:27514991 PMID:28965971 PMID:31614463 PMID:31646340 PMID:36828454 | Myc | increases mutagenesis | ISO | Myc (Mus musculus) | 6480464 | CTD | Estradiol results in increased mutagenesis of MYC gene | PMID:19139166 | Myc | multiple interactions | ISO | Myc (Mus musculus) | 6480464 | CTD | [Estradiol co-treated with Progesterone] results in increased expression of MYC mRNA; AICDA protein affects the reaction [Estradiol results in increased mutagenesis of MYC gene]; Dronabinol inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; Progesterone promotes the reaction [Estradiol results in increased expression of MYC mRNA] | PMID:18556351 PMID:19139166 PMID:8390853 | Myc | multiple interactions | ISO | MYC (Homo sapiens) | 6480464 | CTD | 4-fluorobenzoyl-TN-14003 inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; [Estradiol binds to ESR2 protein] which results in decreased expression of MYC mRNA; [Estradiol co-treated with EGF protein] results in increased expression of MYC mRNA; [NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein; [Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased expression of MYC protein; afimoxifene inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; BRCA1 protein affects the reaction [Estradiol results in increased expression of MYC mRNA]; ESR1 protein affects the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]; Estradiol promotes the reaction [MYC protein binds to DEK promoter]; Fulvestrant inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; GPER1 protein affects the reaction [Estradiol results in increased expression of MYC mRNA]; IGF1R mutant form promotes the reaction [Estradiol results in increased expression of MYC mRNA]; JUN mutant form inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; JUN mutant form inhibits the reaction [Estradiol results in increased expression of MYC protein]; methoxyacetic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; methylselenic acid inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; MYC protein promotes the reaction [Estradiol results in increased expression of GLS protein]; Raloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; SU 6656 inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; Tamoxifen inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYC mRNA] | PMID:15528270 PMID:15833885 PMID:16051634 PMID:16093440 PMID:16155795 PMID:16327978 PMID:17157789 PMID:18997820 PMID:19244106 PMID:19584281 PMID:19654927 PMID:19698761 PMID:20049119 PMID:20219890 PMID:20404318 PMID:22453024 PMID:23071688 PMID:23094148 PMID:24758408 PMID:26502914 PMID:27514991 PMID:31646340 | | ||||||||||||||||||||||
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