GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp7 | affects response to substance | ISO | MMP7 (Homo sapiens) | 6480464 | CTD | MMP7 promoter SNP affects the susceptibility to Nicotine | PMID:25847246 | Mmp7 | increases expression | ISO | MMP7 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 protein | PMID:20061081 PMID:25847246 | Mmp7 | multiple interactions | ISO | Mmp7 (Mus musculus) | 6480464 | CTD | [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] | PMID:20230807 | Mmp7 | multiple interactions | ISO | MMP7 (Homo sapiens) | 6480464 | CTD | CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA] | PMID:20061081 PMID:25847246 | | ||||||||||||||||||||||
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