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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:67271
Term: MK-2206
Definition: An organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted by 4-(1-aminocyclobutyl)phenyl and phenyl groups at positions 8 and 9, respectively. It is an allosteric Akt inhibitor.
Chemical ID: MESH:C548887
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDMK 2206 results in decreased phosphorylation of MAPK3 proteinPMID:30723155
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[MK 2206 co-treated with mirdametinib] results in decreased phosphorylation of MAPK3 proteinPMID:27634878
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDU 0126 promotes the reaction [MK 2206 results in decreased phosphorylation of MAPK3 protein]PMID:30723155
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