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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3affects localizationEXP 6480464CTDHexachlorobenzene affects the localization of MAPK3 proteinPMID:22245120
Mapk3increases phosphorylationEXP 6480464CTDHexachlorobenzene results in increased phosphorylation of MAPK3 proteinPMID:23708402
Mapk3multiple interactionsEXP 6480464CTD[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 proteinPMID:23708402
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDHexachlorobenzene results in increased phosphorylation of MAPK3 proteinPMID:26219504 PMID:26358519
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDHexachlorobenzene results in increased phosphorylation of MAPK3 proteinPMID:28923513
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]PMID:21205633 PMID:26358519
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