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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:28197
Term: daidzein
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.
Chemical ID: MESH:C004742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTDdaidzein promotes the reaction [GNB1 protein results in increased activity of PLCB2 protein results in increased activity of MAPK3 protein]; daidzein results in increased phosphorylation of and results in increased activity of MAPK3 proteinPMID:16972265
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDdaidzein results in increased phosphorylation of MAPK3 proteinPMID:16840783
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDdaidzein results in increased phosphorylation of MAPK3 proteinPMID:24859791
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDAG 1879 inhibits the reaction [daidzein results in increased phosphorylation of MAPK3 protein]PMID:16840783
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