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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases expressionEXP 6480464CTDOzone results in increased expression of MAPK3 mRNAPMID:35737395
Mapk3multiple interactionsEXP 6480464CTD[Ozone co-treated with Chlorine] results in decreased expression of MAPK3 mRNAPMID:18636392
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDOzone results in increased phosphorylation of MAPK3 proteinPMID:19536146 PMID:29925859
Mapk3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDOzone results in increased phosphorylation of MAPK3 proteinPMID:21543283
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDSCH772984 inhibits the reaction [Ozone results in increased phosphorylation of MAPK3 protein]PMID:29925859
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDOzone results in increased phosphorylation of and results in increased activity of MAPK3 protein; TNF protein affects the reaction [Ozone results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:18207479
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