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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:22689
Term: bafilomycin A1
Definition: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.
Chemical ID: MESH:C040929
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases expressionISOMAPK3 (Homo sapiens)6480464CTDbafilomycin A1 results in increased expression of MAPK3 protein modified formPMID:28483490
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDbafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK3 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]PMID:20371669 PMID:28483490 PMID:32645460
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