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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2998
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlrincreases expressionEXP 6480464CTDSimvastatin results in increased expression of LDLR mRNAPMID:18640378
Ldlrmultiple interactionsEXP 6480464CTDBerberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]PMID:18640378
Ldlraffects response to substanceISOLDLR (Homo sapiens)6480464CTDLDLR 3' UTR polymorphism affects the susceptibility to Simvastatin; LDLR mutant form affects the susceptibility to SimvastatinPMID:10208479 PMID:11181283 PMID:11600564 PMID:11849659 PMID:20413733 PMID:8457250 PMID:9633944
Ldlrincreases activityISOLDLR (Homo sapiens)6480464CTDSimvastatin results in increased activity of LDLR proteinPMID:11728391 PMID:8593127
Ldlrincreases expressionISOLdlr (Mus musculus)6480464CTDSimvastatin results in increased expression of LDLR mRNAPMID:22120639
Ldlrincreases expressionISOLDLR (Homo sapiens)6480464CTDSimvastatin results in increased expression of LDLR mRNA; Simvastatin results in increased expression of LDLR proteinPMID:10357840 PMID:1627634 PMID:17980884 PMID:19383813 PMID:20018177
Ldlrmultiple interactionsISOLDLR (Homo sapiens)6480464CTD[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB; [Simvastatin co-treated with Ezetimibe] results in increased expression of LDLR mRNA; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]PMID:17980884 PMID:20413733
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