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GENE - TERM ANNOTATION REPORT

RGD ID: 2981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
Acc ID: DOID:9008443
Term: Colorectal Neoplasms
Definition: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Definition Source(s): MESH:D015179
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kras ISOKRAS (Homo sapiens)11060146RGDDNA:missense mutations: :p.G12C, p.G12D, p.G13D (human) 
Kras ISOKras (Mus musculus)11568690RGD  
Kras ISOKRAS (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:20565773 PMID:21369707 PMID:25280562
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