Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2926
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Itgam
Name:	integrin subunit alpha M

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Itgam	increases expression	EXP		329901912	RGD	PMA increases expression of Itgam protein on neutrophils
Itgam	increases expression	ISO	ITGAM (Homo sapiens)	329901662	RGD	PMA increases expression of ITGAM protein on monocytes
Itgam	increases expression	ISO	ITGAM (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of ITGAM mRNA; Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein	PMID:16430862 PMID:16617325 PMID:18500357 PMID:19135038 PMID:19428933 PMID:26330309 PMID:30218697 PMID:34506768 PMID:36269090
Itgam	increases expression	ISO	Itgam (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein	PMID:29458014
Itgam	increases localization	ISO	ITGAM (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein	PMID:10739673
Itgam	multiple interactions	ISO	ITGAM (Homo sapiens)	6480464	CTD	2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]; [salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGAM protein; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGAM mRNA; dimemorfan inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein]; fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of ITGAM mRNA]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]	PMID:10739673 PMID:11504768 PMID:18500357 PMID:21331654 PMID:26330309
Itgam	multiple interactions	ISO	Itgam (Mus musculus)	6480464	CTD	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein]	PMID:29458014

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