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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of IL4 mRNA; Cyclophosphamide results in increased expression of IL4 proteinPMID:11948286 PMID:18848347
Il4decreases expressionISOIl4 (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of IL4 mRNA; Cyclophosphamide results in decreased expression of IL4 proteinPMID:11014644 PMID:32151603 PMID:37853057
Il4increases expressionISOIl4 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of IL4 mRNA; Cyclophosphamide results in increased expression of IL4 proteinPMID:11006010 PMID:22842586
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTDFungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]; ganoderic acid C2 inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]PMID:32151603 PMID:37853057
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