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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4decreases expressionISOIl4 (Mus musculus)6480464CTDProgesterone results in decreased expression of IL4 proteinPMID:15804489
Il4increases expressionISOIL4 (Homo sapiens)6480464CTDProgesterone results in increased expression of IL4 mRNAPMID:22615136
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTDProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of ARG1 mRNA]; Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IL12B mRNA]; Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA]; Progesterone inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]; Progesterone inhibits the reaction [IL4 protein results in increased expression of MRC1 mRNA]; Progesterone inhibits the reaction [IL4 protein results in increased expression of RETNLA mRNA]; Progesterone promotes the reaction [[IL4 protein co-treated with Lipopolysaccharides] results in increased expression of CHIL3 mRNA]; Progesterone promotes the reaction [[IL4 protein co-treated with Lipopolysaccharides] results in increased expression of RETNLA mRNA]; Progesterone promotes the reaction [IL4 protein results in increased expression of CHIL3 mRNA]PMID:21977998
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