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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4increases expressionEXP 6480464CTDTrichloroethylene results in increased expression of IL4 proteinPMID:18006135
Il4decreases expressionISOIl4 (Mus musculus)6480464CTDTrichloroethylene results in decreased expression of IL4 mRNA; Trichloroethylene results in decreased expression of IL4 proteinPMID:10774820 PMID:22407948
Il4decreases secretionISOIl4 (Mus musculus)6480464CTDTrichloroethylene results in decreased secretion of IL4 proteinPMID:22407948
Il4increases expressionISOIl4 (Mus musculus)6480464CTDTrichloroethylene results in increased expression of IL4 mRNA; Trichloroethylene results in increased expression of IL4 proteinPMID:15363585 PMID:24974766
Il4increases response to substanceISOIL4 (Homo sapiens)6480464CTDIL4 gene polymorphism results in increased susceptibility to TrichloroethylenePMID:19351467
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTD[Trichloroethylene co-treated with Dietary Fats] results in increased expression of IL4 mRNA; allyl sulfide inhibits the reaction [Trichloroethylene results in decreased expression of IL4 protein]; SB 290157 inhibits the reaction [Trichloroethylene results in increased expression of IL4 protein]PMID:10774820 PMID:24974766 PMID:29669109
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