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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]PMID:31168027
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDKetoconazole results in increased expression of IL1B mRNAPMID:28138970
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDKetoconazole results in increased expression of IL1B mRNAPMID:28138970 PMID:32816093
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDKetoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein]PMID:17966066 PMID:34627953
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