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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:34505
Term: 8-epi-prostaglandin F2alpha
Definition: An isoprostane that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.
Chemical ID: MESH:C075750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases abundanceEXP 6480464CTDIL1B protein results in increased abundance of 8-epi-prostaglandin F2alphaPMID:11530235
Il1bmultiple interactionsEXP 6480464CTDpyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]PMID:11530235
Il1bincreases abundanceISOIL1B (Homo sapiens)6480464CTDIL1B protein results in increased abundance of 8-epi-prostaglandin F2alphaPMID:19751497
Il1bincreases chemical synthesisISOIL1B (Homo sapiens)6480464CTDIL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alphaPMID:16529823
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]PMID:16529823 PMID:19751497
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