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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1a
Name: interleukin 1 alpha
Acc ID: CHEBI:3020
Term: benzalkonium chloride
Definition: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.
Chemical ID: MESH:D001548
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1aincreases expressionISOIl1a (Mus musculus)6480464CTDBenzalkonium Compounds results in increased expression of IL1A proteinPMID:30517752
Il1aincreases expressionISOIL1A (Homo sapiens)6480464CTDBenzalkonium Compounds results in increased expression of IL1A mRNA; Benzalkonium Compounds results in increased expression of IL1A proteinPMID:12781210 PMID:25290854 PMID:30240708 PMID:8006454
Il1aincreases secretionISOIL1A (Homo sapiens)6480464CTDBenzalkonium Compounds results in increased secretion of IL1A proteinPMID:12781210
Il1amultiple interactionsISOIl1a (Mus musculus)6480464CTD[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL1A proteinPMID:31158415
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