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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2887
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il15
Name: interleukin 15
Acc ID: CHEBI:37943
Term: colistin
Definition: A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Chemical ID: MESH:D003091
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il15increases expressionEXP 6480464CTDColistin results in increased expression of IL15 proteinPMID:33882723
Il15multiple interactionsEXP 6480464CTDdapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]]PMID:33882723
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