Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2872
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Igfbp1
Name:	insulin-like growth factor binding protein 1

Acc ID:	CHEBI:27881
Term:	resveratrol
Definition:	A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID:	MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Igfbp1	increases expression	EXP		6480464	CTD	resveratrol results in increased expression of IGFBP1 mRNA	PMID:16236254
Igfbp1	multiple interactions	EXP		6480464	CTD	FOXO1 protein affects the reaction [resveratrol results in increased expression of IGFBP1 mRNA]; resveratrol inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA]	PMID:15788402 PMID:16626303
Igfbp1	increases expression	ISO	IGFBP1 (Homo sapiens)	6480464	CTD	resveratrol results in increased expression of IGFBP1 mRNA	PMID:12154049
Igfbp1	multiple interactions	ISO	IGFBP1 (Homo sapiens)	6480464	CTD	[Plant Extracts co-treated with Resveratrol] results in decreased expression of IGFBP1 mRNA	PMID:23557933
Igfbp1	multiple interactions	ISO	Igfbp1 (Mus musculus)	6480464	CTD	resveratrol promotes the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]	PMID:16917544

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