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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1increases expressionEXP 6480464CTDValproic Acid results in increased expression of IGF1 mRNAPMID:17381134
Igf1affects expressionISOIgf1 (Mus musculus)6480464CTDValproic Acid affects the expression of IGF1 mRNAPMID:17963808
Igf1affects expressionISOIGF1 (Homo sapiens)6480464CTDValproic Acid affects the expression of IGF1 mRNAPMID:25979313
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of IGF1 mRNAPMID:23179753 PMID:29154799
Igf1decreases methylationISOIGF1 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of IGF1 genePMID:29154799
Igf1increases expressionISOIgf1 (Mus musculus)6480464CTDValproic Acid results in increased expression of IGF1 mRNAPMID:24896083
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