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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases expressionISOHspa5 (Mus musculus)6480464CTDochratoxin A results in decreased expression of HSPA5 proteinPMID:19445961
Hspa5decreases expressionISOHSPA5 (Homo sapiens)6480464CTDochratoxin A results in decreased expression of HSPA5 mRNAPMID:19051279
Hspa5decreases methylationISOHSPA5 (Homo sapiens)6480464CTDochratoxin A results in decreased methylation of HSPA5 promoterPMID:30559759
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDochratoxin A metabolite results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 proteinPMID:24356939 PMID:30559759 PMID:33465424 PMID:36058351 PMID:36587836
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of HSPA5 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]; TRAP1 protein affects the reaction [ochratoxin A results in increased expression of HSPA5 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]PMID:33465424 PMID:36587836
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