Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2843
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Hspa5
Name:	heat shock protein family A (Hsp70) member 5

Acc ID:	CHEBI:28077
Term:	rifampicin
Definition:	A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID:	MESH:D012293

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Hspa5	increases expression	EXP		6480464	CTD	Rifampin results in increased expression of HSPA5 protein	PMID:24638036
Hspa5	multiple interactions	EXP		6480464	CTD	ATF4 mutant form inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]	PMID:24638036
Hspa5	increases expression	ISO	HSPA5 (Homo sapiens)	6480464	CTD	Rifampin results in increased expression of HSPA5 mRNA; Rifampin results in increased expression of HSPA5 protein	PMID:27470132 PMID:32535746
Hspa5	multiple interactions	ISO	Hspa5 (Mus musculus)	6480464	CTD	[Rifampin co-treated with Cobicistat] results in increased expression of HSPA5 mRNA	PMID:33629115
Hspa5	multiple interactions	ISO	HSPA5 (Homo sapiens)	6480464	CTD	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]	PMID:27470132

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