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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2796
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hk1
Name: hexokinase 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hk1increases expressionISOHk1 (Mus musculus)6480464CTDParaquat results in increased expression of HK1 proteinPMID:38763349
Hk1multiple interactionsISOHk1 (Mus musculus)6480464CTD[Paraquat co-treated with Maneb] results in decreased expression of HK1 mRNA; HK1 protein affects the reaction [Paraquat results in increased expression of IL6 protein]; HK1 protein affects the reaction [Paraquat results in increased expression of NOS2 protein]; HK1 protein affects the reaction [Paraquat results in increased expression of TNF protein]; U 0126 inhibits the reaction [Paraquat results in increased expression of HK1 protein]PMID:18386188 PMID:38763349
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