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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein]PMID:30104959
Gpx1increases expressionISOGpx1 (Mus musculus)6480464CTDAcetylcysteine results in increased expression of GPX1 proteinPMID:26867644
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]; Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein]; Acetylcysteine inhibits the reaction [rhododendrol results in decreased expression of GPX1 protein]PMID:26867644 PMID:30037311 PMID:35112789
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]PMID:25341683
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