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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:27568
Term: selenium atom
Definition: A chalcogen that has formula Se.
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1affects activityEXP 6480464CTDSelenium affects the activity of GPX1 proteinPMID:19106321
Gpx1affects expressionEXP 6480464CTDSelenium affects the expression of GPX1 mRNAPMID:19106321
Gpx1decreases activityEXP 6480464CTDSelenium deficiency results in decreased activity of GPX1 proteinPMID:12031252 PMID:15203381 PMID:19234057
Gpx1decreases expressionEXP 6480464CTDSelenium deficiency results in decreased expression of GPX1 mRNA; Selenium deficiency results in decreased expression of GPX1 proteinPMID:10949970 PMID:11294903 PMID:11444866 PMID:12031252 PMID:12667700 PMID:15203381 PMID:15670848 PMID:15792362 PMID:17109141 PMID:19234057
Gpx1increases activityEXP 6480464CTDSelenium results in increased activity of GPX1 proteinPMID:10949970 PMID:19022953
Gpx1increases expressionEXP 6480464CTDSelenium results in increased expression of GPX1 mRNA; Selenium results in increased expression of GPX1 proteinPMID:15792362 PMID:19022953 PMID:29324385 PMID:38013145
Gpx1multiple interactionsEXP 6480464CTD[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of GPX1 mRNA; Selenium inhibits the reaction [2-iodohexadecanal results in decreased expression of GPX1 mRNA]; Selenium inhibits the reaction [arsenite results in decreased expression of GPX1 protein]; Selenium inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]; Selenium inhibits the reaction [Potassium Iodide results in decreased expression of GPX1 mRNA]; Selenium results in increased expression of and results in decreased degradation of GPX1 mRNAPMID:11444866 PMID:11463357 PMID:16837816 PMID:29324385 PMID:38013145
Gpx1affects activityISOGpx1 (Mus musculus)6480464CTDSelenium affects the activity of GPX1 proteinPMID:17513408 PMID:19076066
Gpx1affects activityISOGPX1 (Homo sapiens)6480464CTDSelenium affects the activity of GPX1 proteinPMID:19125369
Gpx1affects expressionISOGpx1 (Mus musculus)6480464CTDSelenium affects the expression of GPX1 mRNA; Selenium affects the expression of GPX1 proteinPMID:17709542 PMID:19076066
Gpx1affects response to substanceISOGPX1 (Homo sapiens)6480464CTDGPX1 gene polymorphism affects the susceptibility to Selenium; GPX1 protein polymorphism affects the susceptibility to SeleniumPMID:12810669 PMID:19415410
Gpx1decreases activityISOGpx1 (Mus musculus)6480464CTDSelenium deficiency results in decreased activity of GPX1 proteinPMID:15795427
Gpx1decreases expressionISOGpx1 (Mus musculus)6480464CTDSelenium deficiency results in decreased expression of GPX1 mRNAPMID:15795427 PMID:16170372
Gpx1decreases expressionISOGPX1 (Homo sapiens)6480464CTDSelenium deficiency results in decreased expression of GPX1 mRNAPMID:15670848
Gpx1increases activityISOGPX1 (Homo sapiens)6480464CTDSelenium results in increased activity of GPX1 proteinPMID:15203190 PMID:17150329 PMID:17512462
Gpx1increases expressionISOGPX1 (Homo sapiens)6480464CTDSelenium results in increased expression of GPX1 mRNA; Selenium results in increased expression of GPX1 proteinPMID:10874123 PMID:11776067 PMID:17052796
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDSelenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]; Selenium deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of GPX1 protein]; Selenium deficiency results in decreased expression of and results in decreased activity of GPX1 proteinPMID:16170372 PMID:21775527
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