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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTD[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]]PMID:29284473
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTDalpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of GPX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]PMID:26365763 PMID:36058301
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