Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases activityEXP 6480464CTDLipopolysaccharides results in decreased activity of GPX1 proteinPMID:26360969
Gpx1multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased activity of GPX1 protein]; Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased activity of GPX1 protein]PMID:26360969
Gpx1decreases activityISOGpx1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased activity of GPX1 proteinPMID:35099110
Gpx1decreases expressionISOGpx1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of GPX1 mRNAPMID:22040935
Gpx1increases expressionISOGpx1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of GPX1 proteinPMID:21775527
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTD[Organoselenium Compounds co-treated with Lipopolysaccharides] results in increased expression of GPX1 protein; GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Lipopolysaccharides inhibits the reaction [Indirubin E804 results in decreased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]; lycium barbarum polysaccharide inhibits the reaction [Lipopolysaccharides results in decreased activity of GPX1 protein]; Selenium deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of GPX1 protein]PMID:11498278 PMID:20883674 PMID:21775527 PMID:22040935 PMID:23107598 PMID:35099110
Gpx1multiple interactionsISOGPX1 (Homo sapiens)6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of GPX1 mRNA; [Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein; [Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; [Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Thiomalates results in increased expression of GPX1 protein]; [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]; Thiomalates promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]PMID:21355852 PMID:22777745 PMID:31059760
Go Back to source page   Continue to Ontology report