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GENE - TERM ANNOTATION REPORT

RGD ID: 2661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gapdh IDA 13792614RGDprotein:decreased activity:cerebral cortex, hippocampus 
Gapdh ISOGapdh (Mus musculus)13792614RGDprotein:decreased activity:cerebral cortex, cerebellum 
Gapdh ISOGAPDH (Homo sapiens)13792604RGD  
Gapdh ISOGAPDH (Homo sapiens)13792612RGDDNA:SNPs, haplotypes: :rs740850, rs1060620 (human) 
Gapdh ISOGAPDH (Homo sapiens)13792613RGDprotein:increased S-glutathionylation, decreased activity:inferior parietal cortex 
GapdhonsetISOGAPDH (Homo sapiens)1358618RGDDNA:snps:5' utr, intron: (rs3741916, rs1060621) (human) 
GapdhsusceptibilityISOGAPDH (Homo sapiens)13792611RGDDNA:SNP:5' utr:rs3741916 (human) 
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