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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:35004
Term: Tetrachlorobisphenol A
Definition: A bisphenol that has formula C15H12Cl4O2.
Chemical ID: MESH:C041181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosaffects expressionEXP 6480464CTDtetrachlorodian affects the expression of FOS mRNAPMID:37992829
Fosaffects expressionISOFOS (Homo sapiens)6480464CTDtetrachlorodian affects the expression of FOS mRNAPMID:33582643
Fosincreases expressionISOFos (Mus musculus)6480464CTDtetrachlorodian results in increased expression of FOS mRNAPMID:37992829
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDtetrachlorodian results in increased expression of FOS mRNA; tetrachlorodian results in increased expression of FOS proteinPMID:33582643 PMID:36190352
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDU 0126 inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]PMID:37992829
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [tetrachlorodian results in increased expression of FOS protein]; Fulvestrant inhibits the reaction [tetrachlorodian results in increased expression of FOS protein]; Gefitinib inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS protein]PMID:33582643 PMID:36190352
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