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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDGlyphosate results in increased expression of FOS mRNAPMID:38314887
Fosdecreases expressionISOFos (Mus musculus)6480464CTDGlyphosate results in decreased expression of FOS mRNAPMID:35897073
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDGlyphosate results in decreased expression of FOS mRNAPMID:31295307
Fosincreases expressionISOFos (Mus musculus)6480464CTDGlyphosate results in increased expression of FOS mRNAPMID:35489704
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