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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosmultiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [[Cycloheximide co-treated with Cadmium] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA]PMID:11123204 PMID:12632255 PMID:1696944 PMID:7564102
Fosdecreases expressionISOFos (Mus musculus)6480464CTDDactinomycin results in decreased expression of FOS mRNAPMID:11353138
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDDactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]PMID:11353138 PMID:11568973
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDDactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]PMID:10381381
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