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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2587
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F3
Name: coagulation factor III, tissue factor
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F3decreases expressionISOF3 (Homo sapiens)6480464CTDEnalapril results in decreased expression of F3 proteinPMID:22188725
F3multiple interactionsISOF3 (Homo sapiens)6480464CTDEnalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]PMID:18060435
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