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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:17574
Term: biochanin A
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Chemical ID: MESH:C004541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingEXP 6480464CTDbiochanin A binds to ESR2 proteinPMID:19913605
Esr2decreases expressionEXP 6480464CTDbiochanin A results in decreased expression of ESR2 proteinPMID:34848279
Esr2increases expressionEXP 6480464CTDbiochanin A results in increased expression of ESR2 mRNAPMID:34848279
Esr2multiple interactionsEXP 6480464CTD[Fulvestrant co-treated with biochanin A] results in increased expression of ESR2 mRNA; Fulvestrant inhibits the reaction [biochanin A results in decreased expression of ESR2 protein]PMID:34848279
Esr2affects bindingISOEsr2 (Mus musculus)6480464CTDbiochanin A binds to ESR2 proteinPMID:19913605
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDbiochanin A binds to ESR2 proteinPMID:12224631 PMID:16566672 PMID:19913605
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDbiochanin A binds to and results in increased activity of ESR2 protein; biochanin A inhibits the reaction [Estradiol binds to ESR2 protein]PMID:16076101 PMID:16566672 PMID:33049310 PMID:9751507
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