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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr3
Name: early growth response 3
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr3decreases expressionISOEgr3 (Mus musculus)6480464CTDTretinoin results in decreased expression of EGR3 mRNAPMID:36189433
Egr3increases expressionISOEGR3 (Homo sapiens)6480464CTDTretinoin results in increased expression of EGR3 mRNAPMID:15498508 PMID:33167477
Egr3multiple interactionsISOEgr3 (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EGR3 mRNAPMID:36189433
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