GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | ISO | Egfr (Mus musculus) | 6480464 | CTD | Folic Acid results in decreased expression of EGFR mRNA | PMID:25629700 | Egfr | multiple interactions | ISO | Egfr (Mus musculus) | 6480464 | CTD | [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA; EGFR protein affects the reaction [Folic Acid results in increased expression of HAVCR1 protein]; EGFR protein affects the reaction [Folic Acid results in increased expression of LCN2 protein]; EGFR protein affects the reaction [Folic Acid results in increased expression of PCNA protein]; EGFR protein affects the reaction [Folic Acid results in increased expression of VIM protein]; EGFR protein affects the reaction [Folic Acid results in increased phosphorylation of AKT1 protein]; EGFR protein affects the reaction [Folic Acid results in increased phosphorylation of EGFR protein]; Folic Acid results in increased expression of and results in increased phosphorylation of EGFR protein; Gefitinib inhibits the reaction [Folic Acid results in increased phosphorylation of EGFR protein] | PMID:23255615 PMID:33549593 | | ||||||||||||||||||||||
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