GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | EXP | | 6480464 | CTD | Zinc deficiency results in decreased expression of EGFR mRNA | PMID:12672911 | Egfr | increases phosphorylation | ISO | Egfr (Mus musculus) | 6480464 | CTD | Zinc results in increased phosphorylation of EGFR protein | PMID:11983694 | Egfr | increases phosphorylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Zinc results in increased phosphorylation of EGFR protein | PMID:12915106 PMID:12972402 PMID:15980035 | Egfr | multiple interactions | ISO | Egfr (Mus musculus) | 6480464 | CTD | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA; Zinc promotes the reaction [EGFR protein binds to SRC protein] | PMID:11983694 PMID:33549593 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; AG 1879 inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; HBEGF protein affects the reaction [Zinc results in increased phosphorylation of EGFR protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; Zinc results in increased phosphorylation of and results in increased activity of EGFR protein | PMID:12915106 PMID:12972402 PMID:15980035 PMID:16410015 | | ||||||||||||||||||||||
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