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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:180664
Term: 4-hydroxy-TEMPO
Definition: A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Chemical ID: MESH:C001803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1decreases expressionEXP 6480464CTDtempol results in decreased expression of EDN1 mRNA; tempol results in decreased expression of EDN1 proteinPMID:28039404
Edn1multiple interactionsISOEdn1 (Mus musculus)6480464CTDtempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]PMID:17391658
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