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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1affects activityEXP 6480464CTDEthanol affects the activity of EDN1 proteinPMID:16651399
Edn1increases expressionEXP 6480464CTDEthanol results in increased expression of EDN1 proteinPMID:25289771
Edn1multiple interactionsEXP 6480464CTDcyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein]; nymphayol inhibits the reaction [Ethanol results in increased expression of EDN1 protein]PMID:16651399 PMID:25289771
Edn1increases expressionISOEdn1 (Mus musculus)6480464CTDEthanol results in increased expression of EDN1 mRNAPMID:12193144
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