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GENE - TERM ANNOTATION REPORT

RGD ID: 2526
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
Acc ID: GO:0048018
Term: receptor ligand activity
Definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
Definition Source(s): GOC:kv, GOC:molecular_function_refactoring, GOC:pdt
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HbegfenablesISOHbegf (Mus musculus)1624291RGDMGI:2655703 MGI:2665039 PMID:12621152 PMID:16357442 PMID:21946538

PMID:12621152 PMID:16357442 PMID:21946538
HbegfenablesISOHBEGF (Homo sapiens)1624291RGD PMID:8702723

PMID:8702723
HbegfenablesIEAUniProtKB:Q06186 or ensembl:ENSMUSP000000253631600115EnsemblGO_REF:0000107

GO_REF:0000107
HbegfenablesIEAUniProtKB:Q99075 or ensembl:ENSP000002309901600115EnsemblGO_REF:0000107

GO_REF:0000107
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