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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:76004
Term: dimethyl fumarate
Definition: An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Chemical ID: MESH:C056020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases activityEXP 6480464CTDDimethyl Fumarate results in increased activity of NQO1 proteinPMID:16045903
Nqo1increases expressionEXP 6480464CTDDimethyl Fumarate results in increased expression of NQO1 mRNA; Dimethyl Fumarate results in increased expression of NQO1 proteinPMID:27277809
Nqo1increases activityISONQO1 (Homo sapiens)6480464CTDDimethyl Fumarate results in increased activity of NQO1 proteinPMID:15655414 PMID:28790194
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDDimethyl Fumarate results in increased expression of NQO1 mRNAPMID:27277809 PMID:30248482
Nqo1multiple interactionsISONqo1 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]PMID:27277809
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to StreptonigrinPMID:15655414
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