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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhfr
Name: dihydrofolate reductase
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhfrmultiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Methotrexate results in decreased expression of DHFR mRNA]PMID:30502384
Dhfraffects expressionISODHFR (Homo sapiens)6480464CTDFolic Acid affects the expression of DHFR mRNAPMID:17311948
Dhfrdecreases abundanceISODHFR (Homo sapiens)6480464CTDDHFR gene mutant form results in decreased abundance of Folic AcidPMID:21310277
Dhfrincreases expressionISODHFR (Homo sapiens)6480464CTDFolic Acid results in increased expression of DHFR mRNAPMID:28724658 PMID:31076457
Dhfrmultiple interactionsISODhfr (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNAPMID:20938992
Dhfrmultiple interactionsISODHFR (Homo sapiens)6480464CTD[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA; [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of DHFR mRNA; Leucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid]PMID:21310277 PMID:22975265 PMID:24657277
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