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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDCannabidiol results in decreased activity of CYP1A2 proteinPMID:24667653
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDCannabidiol results in increased expression of CYP1A2 mRNAPMID:31052254
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Plant Extracts results in increased abundance of Cannabidiol] which results in increased expression of CYP1A2 mRNAPMID:33096940
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