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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:64050
Term: N-desmethylclozapine
Definition: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
Chemical ID: MESH:C058272
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases chemical synthesisISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased chemical synthesis of norclozapinePMID:18809730
Cyp1a2increases metabolic processingISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased metabolism of norclozapinePMID:12969762
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]PMID:11151749 PMID:18809730
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