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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases hydroxylationEXP 6480464CTDCYP1A2 protein results in increased hydroxylation of TamoxifenPMID:15587933
Cyp1a2decreases activityISOCyp1a2 (Mus musculus)6480464CTDTamoxifen results in decreased activity of CYP1A2 proteinPMID:18420780
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDTamoxifen metabolite results in increased activity of CYP1A2 proteinPMID:29285606
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of TamoxifenPMID:29285606
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; [CYP1A2 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butenePMID:23397584 PMID:29285606
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