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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:35299
Term: dibenz[a,h]anthracene
Definition: An ortho-fused polycyclic arene that has formula C22H14.
Chemical ID: MESH:C026486
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsEXP 6480464CTD[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of CYP1A2 mRNA; [1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of CYP1A2 mRNA; [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP1A2 mRNAPMID:18711122
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTD1,2,5,6-dibenzanthracene results in decreased activity of CYP1A2 proteinPMID:11162773
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTD1,2,5,6-dibenzanthracene results in increased activity of CYP1A2 proteinPMID:19362136
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTD1,2,5,6-dibenzanthracene results in increased expression of CYP1A2 mRNAPMID:16269432 PMID:17253728
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracenePMID:8638931
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of 1,2,5,6-dibenzanthracene; EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracene]PMID:8961944
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of 1,2,5,6-dibenzanthracene; [CYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-1,2-dihydrodiol; [CYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-3,4-dihydrodiol; alyssin inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A2 protein]; EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracene]; sulforaphane inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A2 protein]PMID:17690111 PMID:19362136 PMID:8638931 PMID:8961944
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