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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:28145
Term: dibenzofuran
Definition: A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.
Chemical ID: MESH:C023614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases activityISOCyp1a2 (Mus musculus)6480464CTDdibenzofuran results in increased activity of CYP1A2 proteinPMID:8001243
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDdibenzofuran metabolite results in increased activity of CYP1A2 proteinPMID:26032510
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNAPMID:7750161
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