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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:1784
Term: biphenyl-4-amine
Definition: An aminobiphenyl that is biphenyl substituted by an amino group at position 4.
Chemical ID: MESH:C006757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases oxidationEXP 6480464CTDCYP1A2 protein results in increased oxidation of 4-biphenylaminePMID:2908851
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of 4-biphenylaminePMID:2655891
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased activity of 4-biphenylaminePMID:15450435
Cyp1a2increases metabolic processingISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased metabolism of 4-biphenylaminePMID:11376689
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 4-biphenylamine; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 4-biphenylaminePMID:16988941 PMID:23898916
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