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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16164
Term: pyrogallol
Definition: A benzenetriol carrying hydroxy groups at positions 1, 2 and 3.
Chemical ID: MESH:D011748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases activityISOCyp1a2 (Mus musculus)6480464CTDPyrogallol results in increased activity of CYP1A2 proteinPMID:18789925
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDPyrogallol results in increased expression of CYP1A2 mRNAPMID:18789925
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDresveratrol inhibits the reaction [Pyrogallol results in increased activity of CYP1A2 protein]; resveratrol inhibits the reaction [Pyrogallol results in increased expression of CYP1A2 mRNA]PMID:18789925
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